Single-cell metabolic imaging reveals a RhoA-triggered glycolytic burst in motile endothelial cells. Wu D, Harrison D, Szasz T, Yeh CF, Shentu TP, Meliton A, Huang RT, Zhou Z, Mutlu GM, Huang J, Fang Y. Nature Metabolism. In press.

SARS-CoV-2 infection is associated with reduced Krüppel-Like Factor 2 in human lung autopsy. Lee TH, Wu D, Huang RT, Guzy R, Schoettler N, Adegunsoye A, Mueller J, Hussein A, Sperling A, Mutlu GM, Fang Y. American Journal of Respiratory Cell and Molecular Biology. In press. 

Lee TH, Yeh CF, Lee YT, Shih YC, Chen YT, Hung CT, You MY, Wu PC, Shentu TP, Huang RT, Lin YS, Wu YF, Lin SJ, Lu FL, Tsao PN, Lin TH, Lo SC, Tseng YS, Wu WL, Chen CN, Wu CC, Lin SL, Sperling A, Guzy R, Fang F, Yan KC.  Fibroblast-enriched Endoplasmic Reticulum Protein TXNDC5 Promotes Pulmonary Fibrosis by Augmenting TGFβ Signaling through TGFBR1 Stabilization. Nature Communications.  In Press. , MD. , PhD 1,2,6*

Stolze LK, Conklin AC, Whalen MB, López Rodríguez M, Õunap K, Selvarajan I, Toropainen A, Örd T, Li J, Eshghi A, Solomon AE, Fang Y, Kaikkonen MU, Romanoski CE.  Systems Genetics in Human Endothelial Cells Identifies Non=coding Variants Modifiying Enhancers, Expression, and Complex Disease Traits. Am J Hum Genet. 2020 May 16:S0002-9297(20)30117-8. PMID: 32442411

Lee YV, Wu D, Fang Y, Peng Y, Tian B. Tracking Longitudinal Rotation of Silicon Nanowires for Biointerfaces. In Press. Nano Lett. 2020.

Mehta V, Pang KL, Rozbesky D, Nather K, Keen A, Lachowski D, Kong Y, Karia D, Ameismeier M, Huang J, Fang Y, Del Rio Hernandez A, Reader JS, Jones EY, Tzima E. The guidance receptor Plexin D1 moonlights as an endothelial mechanosensor. Nature. 578(7794):290-295. 2020. 

Krause M, Huang RT, Wu D, Shentu TP, Harrison DL, Whalen MB, Stolze LK, Di Rienzo A, Moskowitz IP, Civelek M, Romanoski CE, Fang Y*. Genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamics. Proc Natl Acad Sci U S A. 115(48): E11349-E11358. 2018. PMC6275533

Fang Y*, Wu D, Birukov KG. Mechanosensing and mechanoregulation of endothelial cell functions. Comprehensive Physiology. 2019; 9(2):873-904. PMID: 30873580

Allon M, Litovsky SH, Tey JC, Sundberg CA, Zhang Y, Chen Z, Fang Y, Cheung AK, Shiu YT. Abnormalities of vascular histology and collagen fiber configuration in patients with advanced chronic kidney disease. J Vasc Access. 2019. 20(1):31-40.

Harrison D, Fang Y*, Huang J*. T-Cell Mechanobiology: Force sensation, potentiation, and translation. Front Phys. 2019; 7: Article 45.  

Shih YC, Chen CL, Zhang Y, Mellor RL, Kanter EM, Fang Y, Wang HC, Hung CT, Nong JY, Chen HJ, Lee TH, Tseng YS, Chen CN, Wu CC, Lin SL, Yamada KA, Nerbonne JM, Yang KC. Endoplasmic Reticulum Protein TXNDC5 Augments Myocardial Fibrosis by Facilitating Extracellular Matrix Protein Folding and Redox-Sensitive Cardiac Fibroblast Activation. Circ Res. 2018. 122(8):1052-1068.

Fancher I, Ahn A, Adamos C, Osborn C, Oh MJ, Fang Y, Reardon C, Getz G, Phillips S, Levitan I. Hypercholesterolemia-induced loss of flow-induced vasodilation and lesion formation in Apoe-/- mice critically depend on Kir channels. J Am Heart Assoc. 2018. 7(5). pii: e007430.

LeMaster E, Huang RT, Zhang C, Bogachkov Y, Coles C, Shentu TP, Sheng Y, Fancher I, Ng C, Christoforidis T, Subbaiah PV, Berdyshev E, Qain Z, Eddington D, Lee J,  Cho M, Fang Y, Minshall RD, LevitanI. Pro-atherogenic flow increases endothelial stiffness via enhanced CD36-mediated oxLDL uptake. Arterioscler Thromb Vasc Biol. 38(1):64-75, 2018.

Mack JJ, Mosqueiro TS, Archer BJ, Jones WM, Sunshine H, Faas GC, Briot A, Hernandez-Solis R, Su YT, Romay MC, McDonald AI, Kuo CH, Lizama CO, Lane TF, Zovein AC, Fang Y, Tarling EJ, Aguiar Vallim TQ, Navab M, Fogelman AM, Bouchard LS, Iruela-Arispe ML. NOTCH1 is an endothelial mechanosensor in adult arteries. Nat Commun. 8(1):1620. 2017.

Poon, C, Chowdhuri S, Kuo CH, Fang Y, Alenghat F, Hyatt D, Kani K, Gross M, Chung, EJ. Protein mimetic properties of monocyte-targeting peptide amphiphile micelles. ACS Biomater Sci Eng. 3(12):3273-3282. 2017.

Wu D, Huang RT, Hamanaka RB, Krause M, Myung-Jin Oh MJ, Kuo CH, Nigdelioglu R, Meliton A, Witt L, Guohao Dai G, Civelek M, Prabhakar NR 4, Fang Y*, Mutlu GM*. HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium. Elife pii: e25217, 2017. *denotes co-corresponding authorship.

Huang RT, Wu D, Meliton A, Oh MJ, Krause M, Lloyd JA, Nigdelioglu R, Hamanaka RB, Jain MK, Birukova A, Kress JP, Birukov KG, Mutlu GM, Fang Y*. Experimental lung injury reduces KLF2 to increase endothelial permeability via regulation of RAPGEF3-Rac1 signaling. Am J Respir Crit Care Med, 195(5):639-651, 2017. *denotes corresponding authorship.

Oh, M. J., C. Zhang, E. LeMaster, C. Adamos, E. Berdyshev, Y. Bogachkov, E. E. Kohler, J. Baruah, Y. Fang, D. E. Schraufnagel, K. K. Wary, and I. Levitan. 2016. Oxidized LDL signals through Rho-GTPase to induce endothelial cell stiffening and promote capillary formation. Journal of lipid research 57: 791-808. 2016

Wu C, Huang RT, Kuo CH, Kumar S, Kim CW, Lin YC, Chen YJ, Birukova A, Birukov KG, Dulin NO, Civelek M, Lusis AJ, Loyer X, Tedgui A, Dai G, Jo H, Fang Y*. Mechano-sensitive PPAP2B regulates endothelial responses to athero-relevant hemodynamic forces. Circ Res. 17(4):e41-53, 2015. Accompanying Editorial by Fleming I. *denotes corresponding authorship.

Chung EJ, Mlinar LB, Nord K, Sugimoto MJ, Wonder E, Alenghat FJ, Fang Y, Tirrell M. Monocyte-targeting supramolecular micellar assemblies: A molecular diagnostic tool for atherosclerosis. Adv Healthc Mater. 18;4(3):367-76, 2015.

Kuo CH, Leon L, Chung EJ, Huang RT, Sontag TJ, Reardon CA, Getz GS, Tirrell M*, Fang Y*. Inhibition of atherosclerosis-promoting micrornas via targeted polyelectrolyte complex micelles. J Mater Chem B Mater Biol Med. 2:8142-8153, 2014. *denotes co-corresponding authorship.

Davies PF, Civelek M, Fang Y, Fleming I. The atherosusceptible endothelium: Endothelial phenotypes in complex hemodynamic shear stress regions in vivo. Cardiovasc Res. 99:315-27, 2013.

Fang Y, Davies PF. Site-specific microRNA-92a regulation of Krüppel-Like Factors 4 and 2 in atherosusceptible endothelium. Arterioscler Thromb Vasc Biol. 32:979-987, 2012. Accompanying Editorial by A. Hamik and M. K. Jain.

Fang Y, Shi C, Manduchi E, Civelek M, Davies PF. MicroRNA-10a regulation of pro-inflammatory phenotype in athero-susceptible endothelium in vivo and in vitro. Proc Natl Acad Sci U S A. 107(30):13450-5, 2010.

Davies PF, Civelek M, Fang Y, Guerraty MA, Passerini AG. Endothelial heterogeneity associated with regional athero-susceptibility and adaptation to disturbed blood flow in vivo. Semin Thromb Hemost. 36(3):265-75, 2010.

Levitan I, Fang Y, Rosenhouse-Dantsker A, Romanenko V. Cholesterol and ion channels. Subcell Biochem. 51:509-49, 2010

Mohler ER 3rd*, Fang Y*, Shaffer RG, Moore J, Wilensky RL, Parmacek M, Levitan I. Hypercholesterolemia suppresses Kir channels in porcine bone marrow progenitor cells in vivo. Biochem Biophys Res Commun. 358:317-24, 2007. 

Byfield FJ, Hoffman BD, Romanenko VG, Fang Y, Crocker JC, Levitan I.  Evidence for the role of cell stiffness in modulation of volume-regulated anion channels. Acta Physiol (Oxf). 187:285-94. 2006.

Fang Y, Romanenko VG, Davies PF, Levitan I.  Flow sensitivity of inwardly-rectifying K channels in human aortic endothelium. Proc. of the 3d IASTED Int. Conf on Biomechanics. 163-167, 2006 

Fang Y, Mohler ER 3rd, Hsieh E, Osman H, Hashemi SM, Davies PF, Rothblat GH, Wilensky RL, Levitan I. Hypercholesterolemia suppresses inwardly rectifying K+ channels in aortic endothelium in vitro and in vivo. Circ Res. 98:1064-71, 2006. Accompanying Editorial by W.F. Jackson.  

Fang W, Chen JY, Fang Y, Huang JL.  Epinephrine overdose-associated hypokalemia and rhabdomyolysis in a newborn. Pharmacotherapy. 25: 1266-70. 2005.  

Fang Y, Schram G, Romanenko VG, Shi C, Conti L, Vandenberg CA, Davies PF, Nattel S, Levitan I. Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2. Am J Physiol Cell Physiol. 289: 1134-44, 2005.   

Romanenko VG, Fang Y, Byfield F, Travis AJ, Vandenberg CA, Rothblat GH, Levitan I. Cholesterol sensitivity and lipid raft targeting of Kir2.1 channels. Biophys J. 87: 3850-61, 2004